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首页> 外文OA文献 >Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

机译：髓母细胞瘤的分子亚组：国际转录组，遗传畸变和WNT，SHH，第3组和第4组髓母细胞瘤的临床数据的荟萃分析。

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Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups. However, all these studies reported on different numbers of subgroups. The current consensus is that there are only four core subgroups, which should be termed WNT, SHH, Group 3 and Group 4. Based on this, we performed a meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies. All cases were analyzed by gene expression profiling and for most cases SNP or array-CGH data were available. Data are presented for all medulloblastomas together and for each subgroup separately. For validation purposes, we compared the results of this meta-analysis with another large medulloblastoma cohort (n = 402) for which subgroup information was obtained by immunohistochemistry. Results from both cohorts are highly similar and show how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival. Results from these analyses will form the basis for prospective multi-center studies and will have an impact on how the different subgroups of medulloblastoma will be treated in the future
机译：髓母细胞瘤是儿童时期最常见的恶性脑肿瘤。来自世界各地几个小组的分子研究表明，髓母细胞瘤不是一种疾病，而是包含不同分子亚组的集合。但是，所有这些研究都报告了不同数量的亚组。目前的共识是，只有四个核心亚组，分别称为WNT，SHH，第3组和第4组。在此基础上，我们对550个髓母细胞瘤的全部分子和临床数据进行了荟萃分析，其中包括7个独立的学习。通过基因表达谱分析对所有病例进行分析，并且大多数情况下都可获得SNP或array-CGH数据。一起显示所有髓母细胞瘤的数据，并分别显示每个亚组的数据。为了进行验证，我们将该荟萃分析的结果与另一个大型髓母细胞瘤队列（n = 402）进行了比较，该队列通过免疫组织化学获得了亚组信息。这两个队列的结果非常相似，并且显示了分子亚型在转录组，DNA拷贝数畸变，人口统计学和生存方面的差异。这些分析的结果将构成前瞻性多中心研究的基础，并将对将来如何治疗髓母细胞瘤不同亚组产生影响

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